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RNA surveillance down-regulates expression of nonfunctional κ alleles and detects premature termination within the last κ exon
Random V(D)J junctions would generate nonfunctional and/or out-of-frame sequences in about two-thirds of cases and result in abundant transcripts encoding truncated proteins. Although allelic exclusion at the DNA recombination level ensures that a single allele is functional, the frequent biallelic...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC409926/ https://ncbi.nlm.nih.gov/pubmed/15123815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0305586101 |
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