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RNA surveillance down-regulates expression of nonfunctional κ alleles and detects premature termination within the last κ exon
Random V(D)J junctions would generate nonfunctional and/or out-of-frame sequences in about two-thirds of cases and result in abundant transcripts encoding truncated proteins. Although allelic exclusion at the DNA recombination level ensures that a single allele is functional, the frequent biallelic...
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| Foilsithe in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
National Academy of Sciences
2004
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC409926/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15123815/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0305586101 |
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