RNA surveillance down-regulates expression of nonfunctional κ alleles and detects premature termination within the last κ exon

Random V(D)J junctions would generate nonfunctional and/or out-of-frame sequences in about two-thirds of cases and result in abundant transcripts encoding truncated proteins. Although allelic exclusion at the DNA recombination level ensures that a single allele is functional, the frequent biallelic...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Delpy, Laurent, Sirac, Christophe, Magnoux, Emmanuelle, Duchez, Sophie, Cogné, Michel
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2004
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC409926/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15123815/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0305586101
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