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CRISPR-induced exon skipping is dependent on premature termination codon mutations
In previous studies, CRISPR/Cas9 was shown to induce unexpected exon skipping; however, the mechanism by which this phenomenon is triggered is controversial. By analyzing 22 gene-edited rabbit lines generated using CRISPR/Cas9, we provide evidence of exon skipping at high frequency in premature term...
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| Wydane w: | Genome Biol |
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| Główni autorzy: | , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
BioMed Central
2018
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6193291/ https://ncbi.nlm.nih.gov/pubmed/30333044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1532-z |
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