CRISPR-induced exon skipping is dependent on premature termination codon mutations

In previous studies, CRISPR/Cas9 was shown to induce unexpected exon skipping; however, the mechanism by which this phenomenon is triggered is controversial. By analyzing 22 gene-edited rabbit lines generated using CRISPR/Cas9, we provide evidence of exon skipping at high frequency in premature term...

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Bibliografiska uppgifter
I publikationen:Genome Biol
Huvudupphovsmän: Sui, Tingting, Song, Yuning, Liu, Zhiquan, Chen, Mao, Deng, Jichao, Xu, Yuanyuan, Lai, Liangxue, Li, Zhanjun
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2018
Ämnen:
Short Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6193291/
https://ncbi.nlm.nih.gov/pubmed/30333044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1532-z
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