Premature replacement of μ with α immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell maturation

Sequentially along B cell differentiation, the different classes of membrane Ig heavy chains associate with the Igα/Igβ heterodimer within the B cell receptor (BCR). Whether each Ig class conveys specific signals adapted to the corresponding differentiation stage remains debated. We investigated the...

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Autori principali: Duchez, Sophie, Amin, Rada, Cogné, Nadine, Delpy, Laurent, Sirac, Christophe, Pascal, Virginie, Corthésy, Blaise, Cogné, Michel
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840347/
https://ncbi.nlm.nih.gov/pubmed/20133609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912393107
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