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Light chain inclusion permits terminal B cell differentiation and does not necessarily result in autoreactivity
Mice in which the Jκ cluster was replaced with a VκJκ rearranged gene were studied. More than 90% of B cells from homozygous mutant mice expressed the transgenic κ chain but showed a slightly reduced level of κ transcripts compared with WT B lymphocytes. Light chain inclusion was apparent in 10% of...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1472516/ https://ncbi.nlm.nih.gov/pubmed/16682638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509121103 |
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