Physiological and druggable skipping of immunoglobulin variable exons in plasma cells

The error-prone V(D)J recombination process generates considerable amounts of nonproductive immunoglobulin (Ig) pre-mRNAs. We recently demonstrated that aberrant Ig chains lacking variable (V) domains can be produced after nonsense-associated altered splicing (NAS) events. Remarkably, the expression...

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Detalhes bibliográficos
Publicado no:Cell Mol Immunol
Main Authors: Ashi, Mohamad Omar, Srour, Nivine, Lambert, Jean-Marie, Marchalot, Anne, Martin, Ophélie, Le Noir, Sandrine, Pinaud, Eric, Ayala, Maria Victoria, Sirac, Christophe, Saulière, Jérôme, Moreaux, Jérôme, Cogné, Michel, Delpy, Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804933/
https://ncbi.nlm.nih.gov/pubmed/30127381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-018-0160-6
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