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Uncoupling Splicing From Transcription Using Antisense Oligonucleotides Reveals a Dual Role for I Exon Donor Splice Sites in Antibody Class Switching

Class switch recombination (CSR) changes antibody isotype by replacing Cμ constant exons with different constant exons located downstream on the immunoglobulin heavy (IgH) locus. During CSR, transcription through specific switch (S) regions and processing of non-coding germline transcripts (GLTs) ar...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Front Immunol
Asıl Yazarlar: Marchalot, Anne, Ashi, Mohamad Omar, Lambert, Jean-Marie, Carrion, Claire, Lecardeur, Sandrine, Srour, Nivine, Delpy, Laurent, Le Pennec, Soazig
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2020
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7233311/
https://ncbi.nlm.nih.gov/pubmed/32477332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00780
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