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Mechanisms and Regulation of Nonsense-Mediated mRNA Decay and Nonsense-Associated Altered Splicing in Lymphocytes

The presence of premature termination codons (PTCs) in transcripts is dangerous for the cell as they encode potentially deleterious truncated proteins that can act with dominant-negative or gain-of-function effects. To avoid the synthesis of these shortened polypeptides, several RNA surveillance sys...

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Dettagli Bibliografici
Pubblicato in:Int J Mol Sci
Autori principali: Lambert, Jean-Marie, Ashi, Mohamad Omar, Srour, Nivine, Delpy, Laurent, Saulière, Jérôme
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072976/
https://ncbi.nlm.nih.gov/pubmed/32079193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21041335
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