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A plasma cell differentiation quality control ablates B cell clones with biallelic Ig rearrangements and truncated Ig production
Aberrantly rearranged immunoglobulin (Ig) alleles are frequent. They are usually considered sterile and innocuous as a result of nonsense-mediated mRNA decay. However, alternative splicing can yield internally deleted proteins from such nonproductively V(D)J-rearranged loci. We show that nonsense co...
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| Publicado no: | J Exp Med |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4710196/ https://ncbi.nlm.nih.gov/pubmed/26666261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131511 |
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