IgH 3’ regulatory region increases ectopic class switch recombination

DNA lesions inflicted by activation-induced deaminase (AID) instrumentally initiate the processes reshaping immunoglobulin genes in mature B-cells, from local somatic hypermutation (SHM) to junctions of distant breaks during class switch recombination (CSR). It remains incompletely understood how th...

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Dettagli Bibliografici
Pubblicato in:PLoS Genet
Autori principali: Le Noir, Sandrine, Bonaud, Amélie, Hervé, Bastien, Baylet, Audrey, Boyer, François, Lecardeur, Sandrine, Oruc, Zeliha, Sirac, Christophe, Cogné, Michel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7869978/
https://ncbi.nlm.nih.gov/pubmed/33556079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009288
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