Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

Chronic inflammation is associated with normal and pathological ageing. Here we show that chronic, progressive low-grade inflammation induced by knockout of the nfkb1 subunit of the transcription factor NF-κB induces premature ageing in mice. We also show that these mice have reduced regeneration in...

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Bibliographische Detailangaben
Hauptverfasser: Jurk, Diana, Wilson, Caroline, Passos, João F., Oakley, Fiona, Correia-Melo, Clara, Greaves, Laura, Saretzki, Gabriele, Fox, Chris, Lawless, Conor, Anderson, Rhys, Hewitt, Graeme, Pender, Sylvia LF, Fullard, Nicola, Nelson, Glyn, Mann, Jelena, van de Sluis, Bart, Mann, Derek A., von Zglinicki, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4090717/
https://ncbi.nlm.nih.gov/pubmed/24960204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5172
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