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A Stochastic Step Model of Replicative Senescence Explains ROS Production Rate in Ageing Cell Populations
Increases in cellular Reactive Oxygen Species (ROS) concentration with age have been observed repeatedly in mammalian tissues. Concomitant increases in the proportion of replicatively senescent cells in ageing mammalian tissues have also been observed. Populations of mitotic human fibroblasts cultur...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3281103/ https://ncbi.nlm.nih.gov/pubmed/22359661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032117 |
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