Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence

Aging is an inherently stochastic process, and its hallmark is heterogeneity between organisms, cell types, and clonal populations, even in identical environments. The replicative lifespan of primary human cells is telomere dependent; however, its heterogeneity is not understood. We show that mitoch...

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Detalhes bibliográficos
Main Authors: Passos, João F, Saretzki, Gabriele, Ahmed, Shaheda, Nelson, Glyn, Richter, Torsten, Peters, Heiko, Wappler, Ilka, Birket, Matthew J, Harold, Graham, Schaeuble, Karin, Birch-Machin, Mark A, Kirkwood, Thomas B. L, von Zglinicki, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1858712/
https://ncbi.nlm.nih.gov/pubmed/17472436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0050110
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