Structural rearrangements of a polyketide synthase module during its catalytic cycle

The polyketide synthase (PKS) mega-enzyme assembly line uses a modular architecture to synthesize diverse and bioactive natural products that often constitute the core structures or complete chemical entities for many clinically approved therapeutic agents(1). The architecture of a full-length PKS m...

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Autori principali: Whicher, Jonathan R., Dutta, Somnath, Hansen, Douglas A., Hale, Wendi A., Chemler, Joseph A., Dosey, Annie M., Narayan, Alison R., Håkansson, Kristina, Sherman, David H., Smith, Janet L., Skiniotis, Georgios
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074775/
https://ncbi.nlm.nih.gov/pubmed/24965656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13409
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