Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae

Por Chemler, Joseph A, Yan, Yajun, Koffas, Mattheos AG
Publicado em 2006

Acyl-CoA subunit selectivity in the terminal pikromycin polyketide synthase module: steady-state kinetics and active-site occupancy analysis by FTICR-MS

Por Bonnett, Shilah A., Rath, Christopher M., Shareef, Abdur-Rafay, Joels, Joanna R., Chemler, Joseph A., Håkansson, Kristina, Reynolds, Kevin, Sherman, David H.
Publicado em 2011

Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination

Por Chemler, Joseph A., Tripathi, Ashootosh, Hansen, Douglas A., O'Neil-Johnson, Mark, Williams, Russell B., Starks, Courtney, Park, Sung Ryeol, Sherman, David H.
Publicado no J Am Chem Soc (2015)

Biochemical and Structural Characterization of Germicidin Synthase: Analysis of a Type III Polyketide Synthase that Employs Acyl-ACP as a Starter Unit Donor

Por Chemler, Joseph A., Buchholz, Tonia J., Geders, Todd W., Akey, David L., Rath, Christopher M., Chlipala, George E., Smith, Janet L., Sherman, David H.
Publicado em 2012

Inversion of extender unit selectivity in the erythromycin polyketide synthase by acyltransferase domain engineering

Por Koryakina, Irina, Kasey, Christian, McArthur, John B, Lowell, Andrew N, Chemler, Joseph A, Li, Shasha, Hansen, Douglas A, Sherman, David H, Williams, Gavin J
Publicado no ACS Chem Biol (2016)

Structural rearrangements of a polyketide synthase module during its catalytic cycle

Por Whicher, Jonathan R., Dutta, Somnath, Hansen, Douglas A., Hale, Wendi A., Chemler, Joseph A., Dosey, Annie M., Narayan, Alison R., Håkansson, Kristina, Sherman, David H., Smith, Janet L., Skiniotis, Georgios
Publicado em 2014

Structure of a modular polyketide synthase

Por Dutta, Somnath, Whicher, Jonathan R., Hansen, Douglas A., Hale, Wendi A., Chemler, Joseph A., Congdon, Grady R., Narayan, Alison R., Håkansson, Kristina, Sherman, David H., Smith, Janet L., Skiniotis, Georgios
Publicado no Nature (2014)

Chemoenzymatic total synthesis and structural diversification of tylactone-based macrolide antibiotics through late-stage polyketide assembly, tailoring, and C-H functionalization

Por Lowell, Andrew N., DeMars, Matthew D., Slocum, Samuel T., Yu, Fengan, Anand, Krithika, Chemler, Joseph A., Korakavi, Nisha, Priessnitz, Jennifer K., Park, Sung Ryeol, Koch, Aaron A., Schultz, Pamela J., Sherman, David H.
Publicado no J Am Chem Soc (2017)

A human MUTYH variant linking colonic polyposis to redox degradation of the [4Fe4S](2+) cluster

Por McDonnell, Kevin J., Chemler, Joseph A., Bartels, Phillip L., O’Brien, Elizabeth, Marvin, Monica L., Ortega, Janice, Stern, Ralph H., Raskin, Leon, Li, Guo­Min, Sherman, David H., Barton, Jacqueline K., Gruber, Stephen B.
Publicado no Nat Chem (2018)