Acyl-CoA subunit selectivity in the terminal pikromycin polyketide synthase module: steady-state kinetics and active-site occupancy analysis by FTICR-MS

Polyketide natural products produced by type I modular polyketide synthases (PKSs) are key weapons in our drug arsenal. To reprogram these biosynthetic assembly lines we must first understand the steps that occur within the modular “black boxes”. Herein, key steps of acyl-CoA extender unit selection...

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Main Authors: Bonnett, Shilah A., Rath, Christopher M., Shareef, Abdur-Rafay, Joels, Joanna R., Chemler, Joseph A., Håkansson, Kristina, Reynolds, Kevin, Sherman, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184853/
https://ncbi.nlm.nih.gov/pubmed/21944746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.07.016
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