Identification of Middle Chain Fatty Acyl-CoA Ligase Responsible for the Biosynthesis of 2-Alkylmalonyl-CoAs for Polyketide Extender Unit

Understanding the biosynthetic mechanism of the atypical polyketide extender unit is important for the development of bioactive natural products. Reveromycin (RM) derivatives produced by Streptomyces sp. SN-593 possess several aliphatic extender units. Here, we studied the molecular basis of 2-alkyl...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Miyazawa, Takeshi, Takahashi, Shunji, Kawata, Akihiro, Panthee, Suresh, Hayashi, Teruo, Shimizu, Takeshi, Nogawa, Toshihiko, Osada, Hiroyuki
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2015
Aiheet:
Enzymology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646404/
https://ncbi.nlm.nih.gov/pubmed/26378232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.677195
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