Identification of Middle Chain Fatty Acyl-CoA Ligase Responsible for the Biosynthesis of 2-Alkylmalonyl-CoAs for Polyketide Extender Unit

Understanding the biosynthetic mechanism of the atypical polyketide extender unit is important for the development of bioactive natural products. Reveromycin (RM) derivatives produced by Streptomyces sp. SN-593 possess several aliphatic extender units. Here, we studied the molecular basis of 2-alkyl...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Miyazawa, Takeshi, Takahashi, Shunji, Kawata, Akihiro, Panthee, Suresh, Hayashi, Teruo, Shimizu, Takeshi, Nogawa, Toshihiko, Osada, Hiroyuki
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2015
Pynciau:
Enzymology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646404/
https://ncbi.nlm.nih.gov/pubmed/26378232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.677195
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