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Proofreading of Non-Cognate Acyl Adenylates by an Acyl-CoA Ligase

Aminoacyl-tRNA synthetases remove (proofread) incorrect substrates and thereby prevent errors in protein synthesis. We report enzyme-catalyzed pre-transfer editing by pimeloyl-CoA ligase (BioW), a biotin synthetic enzyme that converts pimelate, a seven carbon dicarboxylic acid, to its CoA ester. The...

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Autori principali: Manandhar, Miglena, Cronan, John E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3927786/
https://ncbi.nlm.nih.gov/pubmed/24269150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.10.010
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