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Proofreading of Non-Cognate Acyl Adenylates by an Acyl-CoA Ligase
Aminoacyl-tRNA synthetases remove (proofread) incorrect substrates and thereby prevent errors in protein synthesis. We report enzyme-catalyzed pre-transfer editing by pimeloyl-CoA ligase (BioW), a biotin synthetic enzyme that converts pimelate, a seven carbon dicarboxylic acid, to its CoA ester. The...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3927786/ https://ncbi.nlm.nih.gov/pubmed/24269150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.10.010 |
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