Identification of Middle Chain Fatty Acyl-CoA Ligase Responsible for the Biosynthesis of 2-Alkylmalonyl-CoAs for Polyketide Extender Unit

Understanding the biosynthetic mechanism of the atypical polyketide extender unit is important for the development of bioactive natural products. Reveromycin (RM) derivatives produced by Streptomyces sp. SN-593 possess several aliphatic extender units. Here, we studied the molecular basis of 2-alkyl...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Miyazawa, Takeshi, Takahashi, Shunji, Kawata, Akihiro, Panthee, Suresh, Hayashi, Teruo, Shimizu, Takeshi, Nogawa, Toshihiko, Osada, Hiroyuki
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646404/
https://ncbi.nlm.nih.gov/pubmed/26378232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.677195
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