Structure-Function Analyses of Cytochrome P450revI Involved in Reveromycin A Biosynthesis and Evaluation of the Biological Activity of Its Substrate, Reveromycin T

Numerous cytochrome P450s are involved in secondary metabolite biosynthesis. The biosynthetic gene cluster for reveromycin A (RM-A), which is a promising lead compound with anti-osteoclastic activity, also includes a P450 gene, revI. To understand the roles of P450revI, we comprehensively characteri...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Principais autores: Takahashi, Shunji, Nagano, Shingo, Nogawa, Toshihiko, Kanoh, Naoki, Uramoto, Masakazu, Kawatani, Makoto, Shimizu, Takeshi, Miyazawa, Takeshi, Shiro, Yoshitsugu, Osada, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239600/
https://ncbi.nlm.nih.gov/pubmed/25258320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.598391
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