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Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton
Staurosporine isolated from Streptomyces sp. TP-A0274 is a member of the family of indolocarbazole alkaloids that exhibit strong antitumor activity. A key step in staurosporine biosynthesis is the formation of the indolocarbazole core by intramolecular C–C bond formation and oxidative decarboxylatio...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1913897/ https://ncbi.nlm.nih.gov/pubmed/17606921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702946104 |
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