Crystal Structure of H(2)O(2)-dependent Cytochrome P450(SPα) with Its Bound Fatty Acid Substrate: INSIGHT INTO THE REGIOSELECTIVE HYDROXYLATION OF FATTY ACIDS AT THE α POSITION

Cytochrome P450(SPα) (CYP152B1) isolated from Sphingomonas paucimobilis is the first P450 to be classified as a H(2)O(2)-dependent P450. P450(SPα) hydroxylates fatty acids with high α-regioselectivity. Herein we report the crystal structure of P450(SPα) with palmitic acid as a substrate at a resolut...

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Detalhes bibliográficos
Main Authors: Fujishiro, Takashi, Shoji, Osami, Nagano, Shingo, Sugimoto, Hiroshi, Shiro, Yoshitsugu, Watanabe, Yoshihito
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191035/
https://ncbi.nlm.nih.gov/pubmed/21719702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.245225
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