Distinct Regioselectivity of Fungal P450 Enzymes for Steroidal Hydroxylation

In this study, we identified two P450 enzymes (CYP5150AP3 and CYP5150AN1) from Thanatephorus cucumeris NBRC 6298 by combination of transcriptome sequencing and heterologous expression in Pichia pastoris. The biotransformation of 11-deoxycortisol and testosterone by Pichia pastoris whole cells coexpr...

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Detalhes bibliográficos
Publicado no:Appl Environ Microbiol
Main Authors: Lu, Wei, Feng, Jinhui, Chen, Xi, Bao, Yun-Juan, Wang, Yu, Wu, Qiaqing, Ma, Yanhe, Zhu, Dunming
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Biotechnology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715852/
https://ncbi.nlm.nih.gov/pubmed/31324634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01182-19
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