Inversion of extender unit selectivity in the erythromycin polyketide synthase by acyltransferase domain engineering

Acyltransferase (AT) domains of polyketide synthases (PKSs) select extender units for incorporation into polyketides and dictate large portions of the structures of clinically relevant natural products. Accordingly, there is significant interest in engineering the substrate specificity of PKS ATs in...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Koryakina, Irina, Kasey, Christian, McArthur, John B, Lowell, Andrew N, Chemler, Joseph A, Li, Shasha, Hansen, Douglas A, Sherman, David H, Williams, Gavin J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347258/
https://ncbi.nlm.nih.gov/pubmed/28103677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00732
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