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Inversion of extender unit selectivity in the erythromycin polyketide synthase by acyltransferase domain engineering
Acyltransferase (AT) domains of polyketide synthases (PKSs) select extender units for incorporation into polyketides and dictate large portions of the structures of clinically relevant natural products. Accordingly, there is significant interest in engineering the substrate specificity of PKS ATs in...
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| Publicado no: | ACS Chem Biol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5347258/ https://ncbi.nlm.nih.gov/pubmed/28103677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00732 |
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