Inversion of extender unit selectivity in the erythromycin polyketide synthase by acyltransferase domain engineering

Acyltransferase (AT) domains of polyketide synthases (PKSs) select extender units for incorporation into polyketides and dictate large portions of the structures of clinically relevant natural products. Accordingly, there is significant interest in engineering the substrate specificity of PKS ATs in...

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Detaylı Bibliyografya
Yayımlandı:ACS Chem Biol
Asıl Yazarlar: Koryakina, Irina, Kasey, Christian, McArthur, John B, Lowell, Andrew N, Chemler, Joseph A, Li, Shasha, Hansen, Douglas A, Sherman, David H, Williams, Gavin J
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347258/
https://ncbi.nlm.nih.gov/pubmed/28103677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00732
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