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Engineering the acyltransferase substrate specificity of assembly line polyketide synthases

Polyketide natural products act as a broad range of therapeutics, including antibiotics, immunosuppressants and anti-cancer agents. This therapeutic diversity stems from the structural diversity of these small molecules, many of which are produced in an assembly line manner by modular polyketide syn...

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Bibliographische Detailangaben
Hauptverfasser: Dunn, Briana J., Khosla, Chaitan
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Royal Society 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3971720/
https://ncbi.nlm.nih.gov/pubmed/23720536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2013.0297
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