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Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase

Polyketides, one of the largest classes of natural products, are often clinically relevant. The ability to engineer polyketide biosynthesis to produce analogs is critically important. Acyltransferases (ATs) of modular polyketide synthases (PKSs) catalyze the installation of malonyl-CoA extenders int...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Kalkreuter, Edward, Bingham, Kyle S., Keeler, Aaron M., Lowell, Andrew N., Schmidt, Jennifer J., Sherman, David H., Williams, Gavin J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044089/
https://ncbi.nlm.nih.gov/pubmed/33850151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22497-2
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