Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase

Polyketides, one of the largest classes of natural products, are often clinically relevant. The ability to engineer polyketide biosynthesis to produce analogs is critically important. Acyltransferases (ATs) of modular polyketide synthases (PKSs) catalyze the installation of malonyl-CoA extenders int...

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Publicat a:Nat Commun
Autors principals: Kalkreuter, Edward, Bingham, Kyle S., Keeler, Aaron M., Lowell, Andrew N., Schmidt, Jennifer J., Sherman, David H., Williams, Gavin J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044089/
https://ncbi.nlm.nih.gov/pubmed/33850151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22497-2
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