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Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase
Polyketides, one of the largest classes of natural products, are often clinically relevant. The ability to engineer polyketide biosynthesis to produce analogs is critically important. Acyltransferases (ATs) of modular polyketide synthases (PKSs) catalyze the installation of malonyl-CoA extenders int...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8044089/ https://ncbi.nlm.nih.gov/pubmed/33850151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22497-2 |
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