Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase

Polyketides, one of the largest classes of natural products, are often clinically relevant. The ability to engineer polyketide biosynthesis to produce analogs is critically important. Acyltransferases (ATs) of modular polyketide synthases (PKSs) catalyze the installation of malonyl-CoA extenders int...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Kalkreuter, Edward, Bingham, Kyle S., Keeler, Aaron M., Lowell, Andrew N., Schmidt, Jennifer J., Sherman, David H., Williams, Gavin J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044089/
https://ncbi.nlm.nih.gov/pubmed/33850151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22497-2
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