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Development of a genetically-encoded biosensor for detection of polyketide synthase extender units in Escherichia coli

The scaffolds of polyketides are constructed via assembly of extender units based on malonyl-CoA and its derivatives that are substituted at the C2-position with diverse chemical functionality. Subsequently, a transcription factor-based biosensor for malonyl-CoA has proven to be a powerful tool for...

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Dettagli Bibliografici
Pubblicato in:ACS Synth Biol
Autori principali: Kalkreuter, Edward, Keeler, Aaron M., Malico, Alexandra A., Bingham, Kyle S., Gayen, Anuran K., Williams, Gavin J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6915837/
https://ncbi.nlm.nih.gov/pubmed/31134799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssynbio.9b00078
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