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Engineering the substrate specificity of a modular polyketide synthase for installation of consecutive non-natural extender units
There is significant interest in diversifying the structures of polyketides to create new analogues of these bioactive molecules. This has traditionally been done by focusing on engineering the acyltransferase (AT) domains of polyketide synthases (PKSs) responsible for the incorporation of malonyl-C...
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| Udgivet i: | J Am Chem Soc |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6556384/ https://ncbi.nlm.nih.gov/pubmed/30676722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b10521 |
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