Llwytho...
Substrate Structure-Activity Relationships Guide Rational Engineering of Modular Polyketide Synthase Ketoreductases
Modular polyketide synthase ketoreductases can set two chiral centers through a single reduction. To probe the basis of stereocontrol, a structure-activity relationship study was performed with three α-methyl, β-ketothioester substrates and four ketoreductases. Since interactions with the β-ketoacyl...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Chem Commun (Camb) |
|---|---|
| Prif Awduron: | , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2015
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4690787/ https://ncbi.nlm.nih.gov/pubmed/26568113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5cc07315d |
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