Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase

Ketoreductase (KR) domains of modular polyketide synthases (PKSs) control the stereochemistry of C2 methyl and C3 hydroxyl substituents of polyketide intermediates. To understand the molecular basis of stereocontrol exerted by KRs, the crystal structure of a KR from the second module of the amphoter...

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Gepubliceerd in:J Struct Biol
Hoofdauteurs: Liu, Chenguang, Yuan, Meijuan, Xu, Xu, Wang, Lei, Keatinge-Clay, Adrian T., Deng, Zixin, Lin, Shuangjun, Zheng, Jianting
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6127857/
https://ncbi.nlm.nih.gov/pubmed/29626512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2018.04.001
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