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Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase
Ketoreductase (KR) domains of modular polyketide synthases (PKSs) control the stereochemistry of C2 methyl and C3 hydroxyl substituents of polyketide intermediates. To understand the molecular basis of stereocontrol exerted by KRs, the crystal structure of a KR from the second module of the amphoter...
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| Publicado no: | J Struct Biol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6127857/ https://ncbi.nlm.nih.gov/pubmed/29626512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2018.04.001 |
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