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Structural studies of an A2-type modular polyketide synthase ketoreductase reveal features controlling α-substituent stereochemistry
Modular polyketide synthase ketoreductases often set two stereocenters when reducing intermediates in the biosynthesis of a complex polyketide. Here we report the 2.60 Å-resolution structure of an A2-type ketoreductase from the eleventh module of the amphotericin polyketide synthase that sets a comb...
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| 出版年: | ACS Chem Biol |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4434595/ https://ncbi.nlm.nih.gov/pubmed/23755878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400161g |
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