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Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase

Polyketides, one of the largest classes of natural products, are often clinically relevant. The ability to engineer polyketide biosynthesis to produce analogs is critically important. Acyltransferases (ATs) of modular polyketide synthases (PKSs) catalyze the installation of malonyl-CoA extenders int...

詳細記述

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書誌詳細
出版年:Nat Commun
主要な著者: Kalkreuter, Edward, Bingham, Kyle S., Keeler, Aaron M., Lowell, Andrew N., Schmidt, Jennifer J., Sherman, David H., Williams, Gavin J.
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2021
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044089/
https://ncbi.nlm.nih.gov/pubmed/33850151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22497-2
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