Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives.

The methylmalonyl coenzyme A (methylmalonyl-CoA)-specific acyltransferase (AT) domains of modules 1 and 2 of the 6-deoxyerythronolide B synthase (DEBS1) of Saccharopolyspora erythraea ER720 were replaced with three heterologous AT domains that are believed, based on sequence comparisons, to be speci...

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Main Authors: Ruan, X, Pereda, A, Stassi, D L, Zeidner, D, Summers, R G, Jackson, M, Shivakumar, A, Kakavas, S, Staver, M J, Donadio, S, Katz, L
Format: Artigo
Sprog:Inglês
Udgivet: 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC179558/
https://ncbi.nlm.nih.gov/pubmed/9335291
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