Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives.
The methylmalonyl coenzyme A (methylmalonyl-CoA)-specific acyltransferase (AT) domains of modules 1 and 2 of the 6-deoxyerythronolide B synthase (DEBS1) of Saccharopolyspora erythraea ER720 were replaced with three heterologous AT domains that are believed, based on sequence comparisons, to be speci...
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| Udgivet i: | J Bacteriol |
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| Principais autores: | , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology (ASM)
1997
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC179558/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9335291/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.179.20.6416-6425.1997 |
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