Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives.

The methylmalonyl coenzyme A (methylmalonyl-CoA)-specific acyltransferase (AT) domains of modules 1 and 2 of the 6-deoxyerythronolide B synthase (DEBS1) of Saccharopolyspora erythraea ER720 were replaced with three heterologous AT domains that are believed, based on sequence comparisons, to be speci...

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Vydáno v:	J Bacteriol
Hlavní autoři:	Ruan, X, Pereda, A, Stassi, D L, Zeidner, D, Summers, R G, Jackson, M, Shivakumar, A, Kakavas, S, Staver, M J, Donadio, S, Katz, L
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1997
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC179558/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9335291/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.179.20.6416-6425.1997
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