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Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination
The structural scaffolds of many complex natural products are produced by multifunctional type I polyketide synthase (PKS) enzymes that operate as bio-synthetic assembly lines. The modular nature of these megaenzymes presents an opportunity to construct custom biocatalysts built in a lego-like fashi...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4666801/ https://ncbi.nlm.nih.gov/pubmed/26230368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b04842 |
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