Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination

The structural scaffolds of many complex natural products are produced by multifunctional type I polyketide synthase (PKS) enzymes that operate as bio-synthetic assembly lines. The modular nature of these megaenzymes presents an opportunity to construct custom biocatalysts built in a lego-like fashi...

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Pubblicato in:J Am Chem Soc
Autori principali: Chemler, Joseph A., Tripathi, Ashootosh, Hansen, Douglas A., O'Neil-Johnson, Mark, Williams, Russell B., Starks, Courtney, Park, Sung Ryeol, Sherman, David H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666801/
https://ncbi.nlm.nih.gov/pubmed/26230368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b04842
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