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Molecular Basis for Olefin Rearrangement in the Gephyronic Acid Polyketide Synthase
Polyketide synthase (PKS) are a rich source of natural products of varied chemical composition and biological significance. Here, we report the characterization of an atypical dehydratase (DH) domain from the PKS pathway for gephyronic acid, an inhibitor of eukaryotic protein synthesis. Using a libr...
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| Pubblicato in: | ACS Chem Biol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6233718/ https://ncbi.nlm.nih.gov/pubmed/30179448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00645 |
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