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Molecular Basis for Olefin Rearrangement in the Gephyronic Acid Polyketide Synthase

Polyketide synthase (PKS) are a rich source of natural products of varied chemical composition and biological significance. Here, we report the characterization of an atypical dehydratase (DH) domain from the PKS pathway for gephyronic acid, an inhibitor of eukaryotic protein synthesis. Using a libr...

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Bibliografski detalji
Izdano u:ACS Chem Biol
Glavni autori: Dodge, Greg J., Ronnow, Danialle, Taylor, Richard E., Smith, Janet L.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233718/
https://ncbi.nlm.nih.gov/pubmed/30179448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00645
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