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Functional Characterization of a Dehydratase Domain from the Pikromycin Polyketide Synthase
Metabolic engineering of polyketide synthase (PKS) pathways represents a promising approach to natural products discovery. The dehydratase (DH) domains of PKSs, which generate an α,β-unsaturated bond through a dehydration reaction, have been poorly studied compared to other domains, likely due to th...
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| Publicat a: | J Am Chem Soc |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4624270/ https://ncbi.nlm.nih.gov/pubmed/26027428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b02325 |
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