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Functional Characterization of a Dehydratase Domain from the Pikromycin Polyketide Synthase

Metabolic engineering of polyketide synthase (PKS) pathways represents a promising approach to natural products discovery. The dehydratase (DH) domains of PKSs, which generate an α,β-unsaturated bond through a dehydration reaction, have been poorly studied compared to other domains, likely due to th...

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Pubblicato in:J Am Chem Soc
Autori principali: Li, Yang, Dodge, Greg J., Fiers, William D., Fecik, Robert A., Smith, Janet L., Aldrich, Courtney C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624270/
https://ncbi.nlm.nih.gov/pubmed/26027428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b02325
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