Polyketide Intermediate Mimics as Probes for Revealing Cryptic Stereochemistry of Ketoreductase Domains

[Image: see text] Among natural product families, polyketides have shown the most promise for combinatorial biosynthesis of natural product-like libraries. Though recent research in the area has provided many mechanistic revelations, a basic-level understanding of kinetic and substrate tolerability...

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Détails bibliographiques
Publié dans:ACS Chem Biol
Auteurs principaux: Li, Yang, Fiers, William D., Bernard, Steffen M., Smith, Janet L., Aldrich, Courtney C., Fecik, Robert A.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2014
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273979/
https://ncbi.nlm.nih.gov/pubmed/25299319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb5006883
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