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Stereochemistry of Reductions Catalyzed by Methyl-Epimerizing Ketoreductase Domains of Polyketide Synthases
Ketoreductase (KR) domains from modular polyketide synthases catalyze reduction of 2-methyl-3-ketoacyl-ACP substrates and in certain cases epimerization of the 2-methyl group as well. The structural and mechanistic basis of epimerization is poorly understood, and only a small number of such KRs been...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3699853/ https://ncbi.nlm.nih.gov/pubmed/23659177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4014776 |
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