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Stereochemistry of Reductions Catalyzed by Methyl-Epimerizing Ketoreductase Domains of Polyketide Synthases

Ketoreductase (KR) domains from modular polyketide synthases catalyze reduction of 2-methyl-3-ketoacyl-ACP substrates and in certain cases epimerization of the 2-methyl group as well. The structural and mechanistic basis of epimerization is poorly understood, and only a small number of such KRs been...

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Main Authors: You, Young-Ok, Khosla, Chaitan, Cane, David E.
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699853/
https://ncbi.nlm.nih.gov/pubmed/23659177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4014776
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