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Recognition of Acyl Carrier Proteins by Ketoreductases in Assembly Line Polyketide Synthases

Ketoreductases (KRs) are the most widespread tailoring domains found in individual modules of assembly line polyketide synthases (PKSs), and are responsible for controlling the configurations of both the α-methyl and β-hydroxyl stereogenic centers in the growing polyketide chain. Because they recogn...

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Publicat a:J Antibiot (Tokyo)
Autors principals: Ostrowski, Matthew P., Cane, David E., Khosla, Chaitan
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4963262/
https://ncbi.nlm.nih.gov/pubmed/27118242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ja.2016.41
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