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Stereospecificity of the Dehydratase Domain of the Erythromycin Polyketide Synthase
[Image: see text] The dehydratase (DH) domain of module 4 of the 6-deoxyerythronolide B synthase (DEBS) has been shown to catalyze an exclusive syn elimination/syn addition of water. Incubation of recombinant DH4 with chemoenzymatically prepared anti-(2R,3R)-2-methyl-3-hydroxypentanoyl-ACP (2a-ACP)...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2959128/ https://ncbi.nlm.nih.gov/pubmed/20925342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja107344h |
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