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Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase

Polyketide metabolites produced by modular type I polyketide synthases (PKS) acquire their chemical diversity through the variety of catalytic domains within modules of the pathway. Methyltransferases are among the least characterized of the catalytic domains common to PKS systems. We determined the...

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Bibliografiske detaljer
Udgivet i:ACS Chem Biol
Main Authors: Skiba, Meredith A., Sikkema, Andrew P., Fiers, William D., Gerwick, William H., Sherman, David H., Aldrich, Courtney C., Smith, Janet L.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224524/
https://ncbi.nlm.nih.gov/pubmed/27723289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00759
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