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Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase

Polyketide metabolites produced by modular type I polyketide synthases (PKS) acquire their chemical diversity through the variety of catalytic domains within modules of the pathway. Methyltransferases are among the least characterized of the catalytic domains common to PKS systems. We determined the...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Skiba, Meredith A., Sikkema, Andrew P., Fiers, William D., Gerwick, William H., Sherman, David H., Aldrich, Courtney C., Smith, Janet L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224524/
https://ncbi.nlm.nih.gov/pubmed/27723289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00759
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