Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase

Polyketide metabolites produced by modular type I polyketide synthases (PKS) acquire their chemical diversity through the variety of catalytic domains within modules of the pathway. Methyltransferases are among the least characterized of the catalytic domains common to PKS systems. We determined the...

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Pubblicato in:ACS Chem Biol
Autori principali: Skiba, Meredith A., Sikkema, Andrew P., Fiers, William D., Gerwick, William H., Sherman, David H., Aldrich, Courtney C., Smith, Janet L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224524/
https://ncbi.nlm.nih.gov/pubmed/27723289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00759
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