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Molecular Basis for Olefin Rearrangement in the Gephyronic Acid Polyketide Synthase
Polyketide synthase (PKS) are a rich source of natural products of varied chemical composition and biological significance. Here, we report the characterization of an atypical dehydratase (DH) domain from the PKS pathway for gephyronic acid, an inhibitor of eukaryotic protein synthesis. Using a libr...
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| Publicat a: | ACS Chem Biol |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6233718/ https://ncbi.nlm.nih.gov/pubmed/30179448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00645 |
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