α-Methylation Follows Condensation in the Gephyronic Acid Modular Polyketide Synthase

C-methyltransferases (MTs) from modular polyketide synthase assembly lines are relatively rare and unexplored domains that are responsible for installing α-methyl groups into nascent polyketide backbones. The stage at which these synthase-embedded enzymes operate during polyketide biosynthesis has y...

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Bibliographic Details
Published in:Chem Commun (Camb)
Main Authors: Wagner, Drew T., Stevens, D. Cole, Mehaffey, M. Rachel, Manion, Hannah R., Taylor, Richard E., Brodbelt, Jennifer S., Keatinge-Clay, Adrian T.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948183/
https://ncbi.nlm.nih.gov/pubmed/27346052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6cc04418b
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