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Molecular Basis for Olefin Rearrangement in the Gephyronic Acid Polyketide Synthase
Polyketide synthase (PKS) are a rich source of natural products of varied chemical composition and biological significance. Here, we report the characterization of an atypical dehydratase (DH) domain from the PKS pathway for gephyronic acid, an inhibitor of eukaryotic protein synthesis. Using a libr...
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| Publicado no: | ACS Chem Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6233718/ https://ncbi.nlm.nih.gov/pubmed/30179448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00645 |
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